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Bottled Abyss
This small vial has a single dose of a fuming, pitch-black poison inside of it. When a creature eats or drinks the poison, it takes 4d6 psychic damage and must make a DC 18 Constitution saving throw. On a failed save, the creature becomes blind and unable to sleep. When an affected creature attempts to rest, their dreams are plagued with terrible nightmares, preventing them from benefiting from a long rest. The creature can reattempt the saving throw once every 24 hours.
The poison lasts until the affected creature succeeds on a saving throw or is cured by the greater restoration, heal, or wish spell.
Used by viscounts against kings, spies against kings, and queens against kings. And, of course, the butler did it.